DegronMD

Uniprot ID: Q5H9F3

Source protein: BCL-6 corepressor-like protein 1

Source gene: BCORL1

Class: DEG_SCF_FBW7_1

Location: 356:363

E3 ligase: FBXW7

DEGRON score: 0.7941

ASA_SCORE: 100.9

COIL: 0.9718

CONS_SCORE: 0.3807

DSS_SCORE: 0.6628

HELIX: 0.0091

FCONS_SCORE: 0.9868

RIG_SCORE: 0.4939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T359P	TCGA-B0-5701	KIRC	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	0.7031
p.T359P	DO16240	KIRC	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	0.7031
p.P353S	TCGA-BH-A0AW	BRCA	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	0.25
p.P353S	DO5005	BRCA	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	0.25
p.T369A	TCGA-BW-A5NP	LIHC	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	0.1667
p.T369A	DO52172	LIHC	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	0.1667
p.P356S	TCGA-EO-A22U	UCEC	TCGA	PMPTPTPS	DEG_SCF_FBW7_1	0.6752
p.P356S	DO43755	UCEC	ICGC	PMPTPTPS	DEG_SCF_FBW7_1	0.6752
p.P356S	ACH-000670	Lung Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	0.6752
p.A348V	SIDM00373	Endometrial Carcinoma	GDSC	PMPTPTPS	DEG_SCF_FBW7_1	0.1111
p.A348V	ACH-000974	Endometrial/Uterine Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	0.1111
p.A348V	ACH-002026	Endometrial/Uterine Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	0.1111
p.S363F	ACH-000777	Esophageal Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	0.7982
p.P360S	ACH-000973	Bladder Cancer	CCLE	PMPTPTPS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9F3	BCL-6 corepressor-like protein 1	DEG_SCF_FBW7_1	356:363	PMPTPTPS	FBXW7	0.7941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons