DegronMD

Uniprot ID: Q5H9F3

Source protein: BCL-6 corepressor-like protein 1

Source gene: BCORL1

Class: DEG_SCF_FBW7_1

Location: 1459:1465

E3 ligase: FBXW7

DEGRON score: 0.9591

ASA_SCORE: 90.2143

COIL: 0.921

CONS_SCORE: 0.9023

DSS_SCORE: 0.7234

HELIX: 0.0577

FCONS_SCORE: 1.1117

RIG_SCORE: 0.5676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1466W	TCGA-A5-A0VP	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.3056
p.H1451Q	TCGA-A5-A1OF	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.1111
p.R1452C	TCGA-AX-A1CE	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.1389
p.T1469N	TCGA-AX-A3FX	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.2222
p.T1469N	ACH-001794	Liposarcoma	CCLE	PCTPSKS	DEG_SCF_FBW7_1	0.2222
p.W1468L	TCGA-BH-A18G	BRCA	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.25
p.S1465F	TCGA-D6-A6EQ	HNSC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.7982
p.R1452S	TCGA-EE-A3AA	SKCM	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.1389
p.A1459T	TCGA-EO-A22T	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.7139
p.T1469I	TCGA-EY-A215	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.2222
p.D1470N	TCGA-FI-A2D5	UCEC	TCGA	PCTPSKS	DEG_SCF_FBW7_1	0.1944
p.P1460L	DO229046	LICA	ICGC	PCTPSKS	DEG_SCF_FBW7_1	0.7582
p.T1457R	DO25985	LUAD	ICGC	PCTPSKS	DEG_SCF_FBW7_1	0.2778
p.Q1455H	DO26374	LUAD	ICGC	PCTPSKS	DEG_SCF_FBW7_1	0.3333
p.D1465G	DO46591	OV	ICGC	PCTPSKS	DEG_SCF_FBW7_1	0.7198
p.L1475R	DO38631	STAD	ICGC	PCTPSKS	DEG_SCF_FBW7_1	0.0556
p.S1474L	DO43755	UCEC	ICGC	PCTPSKS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9F3	BCL-6 corepressor-like protein 1	DEG_SCF_FBW7_1	1459:1465	PCTPSKS	FBXW7	0.9591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons