DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VHTSS
Uniprot ID:
A8MX19
Source protein:
Putative protein FAM90A12P
Source gene:
FAM90A12P
Class:
DEG_SPOP_SBC_1
Location:
152:156
E3 ligase:
SPOP
DEGRON score:
0.9805
ASA_SCORE:
80.68
COIL:
0.8712
CONS_SCORE:
0.322
DSS_SCORE:
0.5981
HELIX:
0.0422
FCONS_SCORE:
0.6795
RIG_SCORE:
0.6706
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A12P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VHTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8MVW5
HEPACAM family member 2
DEG_SPOP_SBC_1
189:193
VHTSS
SPOP
0.8164
More...
Q5H9F3
BCL-6 corepressor-like protein 1
DEG_SPOP_SBC_1
650:654
VHTSS
SPOP
0.9938
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
1851:1855
VHTSS
SPOP
0.5519
More...
A8MX19
Putative protein FAM90A12P
DEG_SPOP_SBC_1
152:156
VHTSS
SPOP
0.9805
More...