DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 1851:1855

E3 ligase: SPOP

DEGRON score: 0.5519

ASA_SCORE: 89.88

COIL: 0.8598

CONS_SCORE: 0

DSS_SCORE: 0.4707

HELIX: 0.0234

FCONS_SCORE: 0

RIG_SCORE: 0.6786

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1841I	TCGA-AA-A01I	COAD	TCGA	VHTSS	DEG_SPOP_SBC_1	0.0556
p.T1841I	DO10510	COAD	ICGC	VHTSS	DEG_SPOP_SBC_1	0.0556
p.G1857E	TCGA-B5-A0JY	UCEC	TCGA	VHTSS	DEG_SPOP_SBC_1	0.2778
p.G1857E	DO220878	MELA	ICGC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.G1857E	DO222595	MELA	ICGC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.G1857E	DO43041	UCEC	ICGC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.L1865F	TCGA-CR-6473	HNSC	TCGA	VHTSS	DEG_SPOP_SBC_1	0.0556
p.L1865F	DO14228	HNSC	ICGC	VHTSS	DEG_SPOP_SBC_1	0.0556
p.T1861I	TCGA-YD-A89C	SKCM	TCGA	VHTSS	DEG_SPOP_SBC_1	0.1667
p.T1861I	DO219501	SKCM	ICGC	VHTSS	DEG_SPOP_SBC_1	0.1667
p.V1851A	DO228941	LICA	ICGC	VHTSS	DEG_SPOP_SBC_1	0.5825
p.A1856T	DO228907	LICA	ICGC	VHTSS	DEG_SPOP_SBC_1	0.3056
p.D1843G	SIDM02059	Colorectal Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.1111
p.H1849R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00454	Rhabdomyosarcoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00654	Small Cell Lung Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00210	Ovarian Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM01112	Osteosarcoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00650	Small Cell Lung Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00854	Burkitt's Lymphoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00849	Kidney Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00863	Burkitt's Lymphoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM01681	Non-Cancerous	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00673	Breast Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00808	Burkitt's Lymphoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM00760	Small Cell Lung Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM01318	Hepatocellular Carcinoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.H1849R	SIDM01254	Burkitt's Lymphoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.2778
p.S1864P	SIDM00212	Glioblastoma	GDSC	VHTSS	DEG_SPOP_SBC_1	0.5278
p.S1864P	CAS-1	central_nervous_system	COSMIC	VHTSS	DEG_SPOP_SBC_1	0.5278
p.S1854R	ACH-001414	Bladder Cancer	CCLE	VHTSS	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MVW5	HEPACAM family member 2	DEG_SPOP_SBC_1	189:193	VHTSS	SPOP	0.8164	More...
Q5H9F3	BCL-6 corepressor-like protein 1	DEG_SPOP_SBC_1	650:654	VHTSS	SPOP	0.9938	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1851:1855	VHTSS	SPOP	0.5519	More...
A8MX19	Putative protein FAM90A12P	DEG_SPOP_SBC_1	152:156	VHTSS	SPOP	0.9805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VHTSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VHTSS