DegronMD - A8MW99(MEI4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R111I	DO8264	COAD	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.2222
p.M99I	DO25320	LUAD	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.2778
p.S115L	DO220902	MELA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.1111
p.S114F	DO229459	SKCA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.1389
p.D105N	DO229456	SKCA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation altering degron motif	0.5821
p.E100K	DO229470	SKCA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.3056
p.G103E	DO37659	SKCM	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation altering degron motif	0.7199
p.S98L	SIDM00234	Other Solid Cancers	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00600	Thyroid Gland Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00544	Neuroblastoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00599	Osteosarcoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00375	Head and Neck Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00381	Cervical Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	SIDM00026	Other Solid Cancers	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	ACH-000705	Lung Cancer	CCLE	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	ACH-000769	Lung Cancer	CCLE	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.S98L	ACH-000843	Lung Cancer	CCLE	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.25
p.D116Y	SIDM00193	Colorectal Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.0833
p.N108S	SIDM00808	Burkitt's Lymphoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	101:107	Mutation rewiring degron network	0.3056

Kaplan plot for MEI4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEI4

UniProt ID: A8MW99

Entrez ID: 101928601

Protein name: Meiosis-specific protein MEI4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEI4 in