DegronMD

Uniprot ID: A8MW99

Source protein: Meiosis-specific protein MEI4

Source gene: MEI4

Class: DEG_SCF_TRCP1_1

Location: 101:107

E3 ligase: BTRC

DEGRON score: 0.9281

ASA_SCORE: 59.1714

COIL: 0.8369

CONS_SCORE: 0.3464

DSS_SCORE: 0.6347

HELIX: 0.102

FCONS_SCORE: 0.8469

RIG_SCORE: 0.6652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R111I	DO8264	COAD	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	0.2222
p.M99I	DO25320	LUAD	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	0.2778
p.S115L	DO220902	MELA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	0.1111
p.S114F	DO229459	SKCA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	0.1389
p.D105N	DO229456	SKCA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	0.5821
p.E100K	DO229470	SKCA	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	0.3056
p.G103E	DO37659	SKCM	ICGC	DSGCDLS	DEG_SCF_TRCP1_1	0.7199
p.S98L	SIDM00234	Other Solid Cancers	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00600	Thyroid Gland Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00544	Neuroblastoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00599	Osteosarcoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00375	Head and Neck Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00381	Cervical Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	SIDM00026	Other Solid Cancers	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	ACH-000705	Lung Cancer	CCLE	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	ACH-000769	Lung Cancer	CCLE	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.S98L	ACH-000843	Lung Cancer	CCLE	DSGCDLS	DEG_SCF_TRCP1_1	0.25
p.D116Y	SIDM00193	Colorectal Carcinoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.0833
p.N108S	SIDM00808	Burkitt's Lymphoma	GDSC	DSGCDLS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MW99	Meiosis-specific protein MEI4	DEG_SCF_TRCP1_1	101:107	DSGCDLS	BTRC	0.9281	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons