DegronMD - A8MXY4(ZNF99)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E861Q	TCGA-05-4382	LUAD	TCGA	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.3056
p.S873L	DO5277	BRCA	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.0833
p.T874S	DO224721	COCA	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.0556
p.N855S	DO227501	LAML	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1389
p.N855S	IHH-4	thyroid	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1389
p.N855S	HCT-15	large intestine	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1389
p.G866S	DO223673	LGG	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.2778
p.N870K	DO26617	LUSC	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1667
p.E861K	DO222396	MELA	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.3056
p.E861K	DO222868	MELA	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.3056
p.E861K	ACH-001560	Lung Cancer	CCLE	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.3056
p.T853I	DO222699	MELA	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.0833
p.G854E	DO47268	SKCM	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1111
p.E855K	DO48665	SKCM	ICGC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1389
p.N862K	SIDM00057	Neuroblastoma	GDSC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.5806
p.N862K	ACH-002389	Neuroblastoma	CCLE	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.5806
p.N862K	ACN	autonomic ganglia	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.5806
p.M863T	SIDM00241	Breast Carcinoma	GDSC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.7423
p.M863T	SIDM00363	Acute Myeloid Leukemia	GDSC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.7423
p.M863T	ACH-000770	Leukemia	CCLE	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.7423
p.M863T	ACH-002179	Breast Cancer	CCLE	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.7423
p.M863T	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.7423
p.M863T	OCUB-M	breast	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.7423
p.E861G	ZR-75-30	breast	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.3056
p.E861G	HCC1569	breast	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.3056
p.C860F	TASK1	bone	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.2778
p.G854V	COLO-792	skin	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1111
p.M863I	ZR-75-30	breast	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.6507
p.M863I	HCC1569	breast	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation altering degron motif	0.6507
p.F869V	TE-8	oesophagus	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.1944
p.T853S	NCI-H1436	lung	COSMIC	NMR	DEG_APCC_TPR_1	862:864	Mutation rewiring degron network	0.0833

Kaplan plot for ZNF99 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF99

UniProt ID: A8MXY4

Entrez ID: 7652

Protein name: Zinc finger protein 99

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF99 in