DegronMD

Uniprot ID: A8MXY4

Source protein: Zinc finger protein 99

Source gene: ZNF99

Class: DEG_APCC_TPR_1

Location: 862:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7129

ASA_SCORE: 130.4667

COIL: 0.942

CONS_SCORE: 0.306

DSS_SCORE: 0.8034

HELIX: 0.0443

FCONS_SCORE: 0.7848

RIG_SCORE: 0.7368

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E861Q	TCGA-05-4382	LUAD	TCGA	NMR	DEG_APCC_TPR_1	0.3056
p.S873L	DO5277	BRCA	ICGC	NMR	DEG_APCC_TPR_1	0.0833
p.T874S	DO224721	COCA	ICGC	NMR	DEG_APCC_TPR_1	0.0556
p.N855S	DO227501	LAML	ICGC	NMR	DEG_APCC_TPR_1	0.1389
p.N855S	IHH-4	thyroid	COSMIC	NMR	DEG_APCC_TPR_1	0.1389
p.N855S	HCT-15	large_intestine	COSMIC	NMR	DEG_APCC_TPR_1	0.1389
p.G866S	DO223673	LGG	ICGC	NMR	DEG_APCC_TPR_1	0.2778
p.N870K	DO26617	LUSC	ICGC	NMR	DEG_APCC_TPR_1	0.1667
p.E861K	DO222396	MELA	ICGC	NMR	DEG_APCC_TPR_1	0.3056
p.E861K	DO222868	MELA	ICGC	NMR	DEG_APCC_TPR_1	0.3056
p.E861K	ACH-001560	Lung Cancer	CCLE	NMR	DEG_APCC_TPR_1	0.3056
p.T853I	DO222699	MELA	ICGC	NMR	DEG_APCC_TPR_1	0.0833
p.G854E	DO47268	SKCM	ICGC	NMR	DEG_APCC_TPR_1	0.1111
p.E855K	DO48665	SKCM	ICGC	NMR	DEG_APCC_TPR_1	0.1389
p.N862K	SIDM00057	Neuroblastoma	GDSC	NMR	DEG_APCC_TPR_1	0.5806
p.N862K	ACH-002389	Neuroblastoma	CCLE	NMR	DEG_APCC_TPR_1	0.5806
p.N862K	ACN	autonomic_ganglia	COSMIC	NMR	DEG_APCC_TPR_1	0.5806
p.M863T	SIDM00241	Breast Carcinoma	GDSC	NMR	DEG_APCC_TPR_1	0.7423
p.M863T	SIDM00363	Acute Myeloid Leukemia	GDSC	NMR	DEG_APCC_TPR_1	0.7423
p.M863T	ACH-000770	Leukemia	CCLE	NMR	DEG_APCC_TPR_1	0.7423
p.M863T	ACH-002179	Breast Cancer	CCLE	NMR	DEG_APCC_TPR_1	0.7423
p.M863T	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	NMR	DEG_APCC_TPR_1	0.7423
p.M863T	OCUB-M	breast	COSMIC	NMR	DEG_APCC_TPR_1	0.7423
p.E861G	ZR-75-30	breast	COSMIC	NMR	DEG_APCC_TPR_1	0.3056
p.E861G	HCC1569	breast	COSMIC	NMR	DEG_APCC_TPR_1	0.3056
p.C860F	TASK1	bone	COSMIC	NMR	DEG_APCC_TPR_1	0.2778
p.G854V	COLO-792	skin	COSMIC	NMR	DEG_APCC_TPR_1	0.1111
p.M863I	ZR-75-30	breast	COSMIC	NMR	DEG_APCC_TPR_1	0.6507
p.M863I	HCC1569	breast	COSMIC	NMR	DEG_APCC_TPR_1	0.6507
p.F869V	TE-8	oesophagus	COSMIC	NMR	DEG_APCC_TPR_1	0.1944
p.T853S	NCI-H1436	lung	COSMIC	NMR	DEG_APCC_TPR_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NMR

Degron related mutations and impact score

Drug responses associated with ZNF99 mutations

All proteins holding degron of NMR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MXY4	Zinc finger protein 99	DEG_APCC_TPR_1	862:864	NMR	APC,CDC20,FZR1	0.7129	More...