DegronMD - B1AKI9(ISM1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D98Y	TCGA-AP-A0LM	UCEC	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.D98Y	DO43306	UCEC	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2778
p.F99L	TCGA-CA-5796	COAD	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.F99L	DO7777	COAD	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.D117H	TCGA-CN-4731	HNSC	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.D117H	DO15886	HNSC	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.P100T	TCGA-D3-A3CE	SKCM	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5919
p.P100T	DO37405	SKCM	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.5919
p.D117N	TCGA-DX-AB2E	SARC	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.D117N	DO220073	SARC	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.0833
p.P111Q	TCGA-EE-A3AH	SKCM	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.P111Q	DO37443	SKCM	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.R97I	TCGA-ND-A4WC	UCS	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.R101I	DO46329	OV	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.8102
p.L105F	SIDM00131	Glioma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.587
p.L105F	SIDM00625	Other Sarcomas	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.587
p.L105F	SIDM01080	Oral Cavity Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.587
p.L105F	SIDM00856	Other Solid Cancers	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.587
p.L105F	SIDM00954	Breast Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.587
p.P100H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6583
p.P100H	ACH-000995	Leukemia	CCLE	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6583
p.P100H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6583
p.H92N	SIDM00878	Breast Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.H92N	ACH-000930	Breast Cancer	CCLE	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.H92N	HCC1569	breast	COSMIC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.F99Y	SIDM01190	Bladder Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.F99Y	ACH-000720	Bladder Cancer	CCLE	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.F99Y	TCCSUP	urinary tract	COSMIC	PRSFLLDLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ISM1

UniProt ID: B1AKI9

Entrez ID: 140862

Protein name: Isthmin-1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ISM1 in