DegronMD

Uniprot ID: B1AKI9

Source protein: Isthmin-1

Source gene: ISM1

Class: DEG_APCC_DBOX_1

Location: 100:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6251

ASA_SCORE: 51.6778

COIL: 0.6266

CONS_SCORE: 0.6074

DSS_SCORE: 0.4396

HELIX: 0.061

FCONS_SCORE: 1.0265

RIG_SCORE: 0.7693

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D98Y	TCGA-AP-A0LM	UCEC	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	0.2778
p.D98Y	DO43306	UCEC	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	0.2778
p.F99L	TCGA-CA-5796	COAD	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	0.3056
p.F99L	DO7777	COAD	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	0.3056
p.D117H	TCGA-CN-4731	HNSC	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	0.0833
p.D117H	DO15886	HNSC	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	0.0833
p.P100T	TCGA-D3-A3CE	SKCM	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	0.5919
p.P100T	DO37405	SKCM	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	0.5919
p.D117N	TCGA-DX-AB2E	SARC	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	0.0833
p.D117N	DO220073	SARC	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	0.0833
p.P111Q	TCGA-EE-A3AH	SKCM	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	0.25
p.P111Q	DO37443	SKCM	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	0.25
p.R97I	TCGA-ND-A4WC	UCS	TCGA	PRSFLLDLP	DEG_APCC_DBOX_1	0.25
p.R101I	DO46329	OV	ICGC	PRSFLLDLP	DEG_APCC_DBOX_1	0.8102
p.L105F	SIDM00131	Glioma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.587
p.L105F	SIDM00625	Other Sarcomas	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.587
p.L105F	SIDM01080	Oral Cavity Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.587
p.L105F	SIDM00856	Other Solid Cancers	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.587
p.L105F	SIDM00954	Breast Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.587
p.P100H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.6583
p.P100H	ACH-000995	Leukemia	CCLE	PRSFLLDLP	DEG_APCC_DBOX_1	0.6583
p.P100H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PRSFLLDLP	DEG_APCC_DBOX_1	0.6583
p.H92N	SIDM00878	Breast Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.1111
p.H92N	ACH-000930	Breast Cancer	CCLE	PRSFLLDLP	DEG_APCC_DBOX_1	0.1111
p.H92N	HCC1569	breast	COSMIC	PRSFLLDLP	DEG_APCC_DBOX_1	0.1111
p.F99Y	SIDM01190	Bladder Carcinoma	GDSC	PRSFLLDLP	DEG_APCC_DBOX_1	0.3056
p.F99Y	ACH-000720	Bladder Cancer	CCLE	PRSFLLDLP	DEG_APCC_DBOX_1	0.3056
p.F99Y	TCCSUP	urinary_tract	COSMIC	PRSFLLDLP	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSFLLDLP

Degron related mutations and impact score

Drug responses associated with ISM1 mutations

All proteins holding degron of PRSFLLDLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B1AKI9	Isthmin-1	DEG_APCC_DBOX_1	100:108	PRSFLLDLP	APC,CDC20,FZR1	0.6251	More...