DegronMD - C9JQI7(TMEM232)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E569Q	TCGA-AY-6196	COAD	TCGA	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.0833
p.E569Q	DO10300	COAD	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.0833
p.F584L	TCGA-BS-A0UV	UCEC	TCGA	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.F584L	TCGA-EO-A3AV	UCEC	TCGA	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.F584L	DO222762	COCA	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.F584L	DO52412	UCEC	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.F584L	DO42793	UCEC	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.K590T	TCGA-EO-A22X	UCEC	TCGA	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation substituting flanking lysine	0.25
p.K590T	DO43907	UCEC	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation substituting flanking lysine	0.25
p.F584V	DO50348	ESAD	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.F584V	DO234445	ESAD	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.H570N	DO228948	LICA	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.1111
p.T586N	DO229045	LICA	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.25
p.K587N	DO230940	LUSC	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation substituting flanking lysine	0.3333
p.K587N	DO224584	LUSC	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation substituting flanking lysine	0.3333
p.P580S	DO222514	MELA	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation altering degron motif	0.6752
p.P580S	DO222731	MELA	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation altering degron motif	0.6752
p.S574L	DO222837	MELA	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.2222
p.E575K	DO232224	PBCA	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.25
p.P577S	DO37426	SKCM	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.3056
p.S572F	DO37409	SKCM	ICGC	MFPYPD	LIG_APCC_ABBA_1	578:583	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM232

UniProt ID: C9JQI7

Entrez ID: 642987

Protein name: Transmembrane protein 232

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM232 in