DegronMD

Uniprot ID: C9JQI7

Source protein: Transmembrane protein 232

Source gene: TMEM232

Class: LIG_APCC_ABBA_1

Location: 578:583

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9839

ASA_SCORE: 86.1

COIL: 0.924

CONS_SCORE: 0.2821

DSS_SCORE: 0.2796

HELIX: 0.0333

FCONS_SCORE: 0.8283

RIG_SCORE: 0.8086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E569Q	TCGA-AY-6196	COAD	TCGA	MFPYPD	LIG_APCC_ABBA_1	0.0833
p.E569Q	DO10300	COAD	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.0833
p.F584L	TCGA-BS-A0UV	UCEC	TCGA	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.F584L	TCGA-EO-A3AV	UCEC	TCGA	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.F584L	DO222762	COCA	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.F584L	DO52412	UCEC	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.F584L	DO42793	UCEC	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.K590T	TCGA-EO-A22X	UCEC	TCGA	MFPYPD	LIG_APCC_ABBA_1	0.25
p.K590T	DO43907	UCEC	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.25
p.F584V	DO50348	ESAD	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.F584V	DO234445	ESAD	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.H570N	DO228948	LICA	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.1111
p.T586N	DO229045	LICA	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.25
p.K587N	DO230940	LUSC	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3333
p.K587N	DO224584	LUSC	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3333
p.P580S	DO222514	MELA	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.6752
p.P580S	DO222731	MELA	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.6752
p.S574L	DO222837	MELA	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.2222
p.E575K	DO232224	PBCA	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.25
p.P577S	DO37426	SKCM	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.3056
p.S572F	DO37409	SKCM	ICGC	MFPYPD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JQI7	Transmembrane protein 232	LIG_APCC_ABBA_1	578:583	MFPYPD	APC,CDC20,FZR1	0.9839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons