MCIDAS
UniProt ID: D6RGH6
Entrez ID: 345643
Protein name: Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963). Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed...
FUNCTION: Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963). Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211). {ECO:0000250|UniProtKB:Q08B36, ECO:0000269|PubMed:21543332, ECO:0000269|PubMed:24064211, ECO:0000269|PubMed:25048963}.
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GO - Biological processes (BP):
cell cycle [GO:0007049]; centriole assembly [GO:0098534]; cilium assembly [GO:0060271]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; positive regu...
cell cycle [GO:0007049]; centriole assembly [GO:0098534]; cilium assembly [GO:0060271]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cilium assembly [GO:1902017]; regulation of DNA-dependent DNA replication initiation [GO:0030174]; regulation of mitotic cell cycle [GO:0007346]
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GO - Molecular function (MF):
identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]...
identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]
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GO - Cellular component (CC):
nuclear body [GO:0016604]; nucleus [GO:0005634]...
nuclear body [GO:0016604]; nucleus [GO:0005634]
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MCIDAS
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Kaplan plot for MCIDAS in
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*NOTE: the Kaplan plots were collected from OncoLnc