DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VSVYED
Uniprot ID:
D6RGH6
Source protein:
Multicilin
Source gene:
MCIDAS
Class:
LIG_APCC_ABBA_1
Location:
57:62
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.999
ASA_SCORE:
76.4
COIL:
0.7517
CONS_SCORE:
0.7468
DSS_SCORE:
0.5733
HELIX:
0.025
FCONS_SCORE:
1.3039
RIG_SCORE:
0.7015
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.C51Y
DO229144
THCA
ICGC
VSVYED
LIG_APCC_ABBA_1
0.1667
p.A70V
DO229245
THCA
ICGC
VSVYED
LIG_APCC_ABBA_1
0.1111
Drug responses associated with MCIDAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSVYED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
D6RGH6
Multicilin
LIG_APCC_ABBA_1
57:62
VSVYED
APC,CDC20,FZR1
0.999
More...