DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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LINC02906
UniProt ID:
E5RJ46
Entrez ID:
Protein name:
Putative uncharacterized protein LINC02906 (Long intergenic non-protein coding RNA 2906)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Open in full screen with detailed sequence annotations
LINC02906
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.R2Q
TCGA-EO-A22U
UCEC
TCGA
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation altering degron motif
0.6218
p.R2Q
DO43755
UCEC
ICGC
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation altering degron motif
0.6218
p.R2Q
ACH-001991
Primary
CCLE
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation altering degron motif
0.6218
p.T12K
DO227906
COCA
ICGC
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation rewiring degron network
0.1944
p.T3N
DO229036
LICA
ICGC
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation altering degron motif
0.7055
p.S15R
DO229006
LICA
ICGC
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation rewiring degron network
0.1111
p.R8Q
DO220899
MELA
ICGC
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation rewiring degron network
0.3056
p.P4L
DO222434
MELA
ICGC
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation altering degron motif
0.7582
p.T7A
DO229453
SKCA
ICGC
MRTPKRT
DEG_SCF_FBW7_1
1:7
Mutation altering degron motif
0.7139
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for LINC02906 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc