DegronMD

Uniprot ID: E5RJ46

Source protein: Putative uncharacterized protein LINC02906

Source gene: LINC02906

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 135.3857

COIL: 0.9621

CONS_SCORE: 1

DSS_SCORE: 0.951

HELIX: 0.0149

FCONS_SCORE: 1.8082

RIG_SCORE: 0.6789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2Q	TCGA-EO-A22U	UCEC	TCGA	MRTPKRT	DEG_SCF_FBW7_1	0.6218
p.R2Q	DO43755	UCEC	ICGC	MRTPKRT	DEG_SCF_FBW7_1	0.6218
p.R2Q	ACH-001991	Primary	CCLE	MRTPKRT	DEG_SCF_FBW7_1	0.6218
p.T12K	DO227906	COCA	ICGC	MRTPKRT	DEG_SCF_FBW7_1	0.1944
p.T3N	DO229036	LICA	ICGC	MRTPKRT	DEG_SCF_FBW7_1	0.7055
p.S15R	DO229006	LICA	ICGC	MRTPKRT	DEG_SCF_FBW7_1	0.1111
p.R8Q	DO220899	MELA	ICGC	MRTPKRT	DEG_SCF_FBW7_1	0.3056
p.P4L	DO222434	MELA	ICGC	MRTPKRT	DEG_SCF_FBW7_1	0.7582
p.T7A	DO229453	SKCA	ICGC	MRTPKRT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E5RJ46	Putative uncharacterized protein LINC02906	DEG_SCF_FBW7_1	1:7	MRTPKRT	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons