DegronMD - O00116(AGPS)

AGPS

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G115V	TCGA-PK-A5HB	ACC	TCGA	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.3056
p.K129T	TCGA-VQ-A8PM	STAD	TCGA	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation substituting flanking lysine	0.3056
p.K129T	DO51772	STAD	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation substituting flanking lysine	0.3056
p.E112K	DO48391	BLCA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.2222
p.G122C	DO228952	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.6489
p.W131C	DO229028	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1389
p.P119T	DO229024	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation altering degron motif	0.5919
p.G109V	DO229026	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1389
p.E130K	DO232761	PBCA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1667
p.V125I	DO38192	STAD	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.3056
p.A131T	DO43186	UCEC	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1389
p.A132D	DO41871	UCEC	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation rewiring degron network	0.1111
p.E127K	MRK-nu-1	breast	COSMIC	KRYPLSGMG	DEG_APCC_DBOX_1	116:124	Mutation blocking phosphorylation signal	0.6944

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*NOTE: the Kaplan plots were collected from OncoLnc