DegronMD

Uniprot ID: O00116

Source protein: Alkyldihydroxyacetonephosphate synthase, peroxisomal

Source gene: AGPS

Class: DEG_APCC_DBOX_1

Location: 116:124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.755

ASA_SCORE: 66.1

COIL: 0.66

CONS_SCORE: 0.3005

DSS_SCORE: 0.2663

HELIX: 0.0629

FCONS_SCORE: 0.8755

RIG_SCORE: 0.7686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G115V	TCGA-PK-A5HB	ACC	TCGA	KRYPLSGMG	DEG_APCC_DBOX_1	0.3056
p.K129T	TCGA-VQ-A8PM	STAD	TCGA	KRYPLSGMG	DEG_APCC_DBOX_1	0.3056
p.K129T	DO51772	STAD	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.3056
p.E112K	DO48391	BLCA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.2222
p.G122C	DO228952	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.6489
p.W131C	DO229028	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.1389
p.P119T	DO229024	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.5919
p.G109V	DO229026	LICA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.1389
p.E130K	DO232761	PBCA	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.1667
p.V125I	DO38192	STAD	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.3056
p.A131T	DO43186	UCEC	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.1389
p.A132D	DO41871	UCEC	ICGC	KRYPLSGMG	DEG_APCC_DBOX_1	0.1111
p.E127K	MRK-nu-1	breast	COSMIC	KRYPLSGMG	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00116	Alkyldihydroxyacetonephosphate synthase, peroxisomal	DEG_APCC_DBOX_1	116:124	KRYPLSGMG	APC,CDC20,FZR1	0.755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons