DegronMD - O00189(AP4M1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R367Q	TCGA-A6-2686	COAD	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.6218
p.R362H	TCGA-AX-A1C9	UCEC	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.8244
p.R367L	TCGA-B5-A1MX	UCEC	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.7316
p.G370E	TCGA-DK-A3X1	BLCA	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.3056
p.G377E	DO447	BLCA	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.1111
p.R374Q	DO7828	COAD	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.1944
p.R374Q	SIDM01079	Melanoma	GDSC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.1944
p.L361P	DO223157	ESCA	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.6471
p.E353K	DO51761	STAD	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation blocking ubiquitination signal	0.5556
p.R369H	DO43098	UCEC	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.8244
p.R374L	DO41999	UCEC	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.1944
p.A361P	SIDM00791	Chronic Myelogenous Leukemia	GDSC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.7503
p.A361P	K-562	haematopoietic and lymphoid tissue	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.7503
p.R374W	SIDM00209	Glioblastoma	GDSC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.1944
p.R374W	D-423MG	central nervous system	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.1944
p.R367W	ACH-002228	Brain Cancer	CCLE	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.7523
p.R367W	D-423MG	central nervous system	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation altering degron motif	0.7523
p.A354P	K-562	haematopoietic and lymphoid tissue	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	361:369	Mutation rewiring degron network	0.1389

Kaplan plot for AP4M1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AP4M1

UniProt ID: O00189

Entrez ID: 9179

Protein name: AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AP4M1 in