DegronMD

Uniprot ID: O00189

Source protein: AP-4 complex subunit mu-1

Source gene: AP4M1

Class: DEG_APCC_DBOX_1

Location: 361:369

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7918

ASA_SCORE: 50.9444

COIL: 0.262

CONS_SCORE: 0.5998

DSS_SCORE: 0.4592

HELIX: 0.0179

FCONS_SCORE: 1.1451

RIG_SCORE: 0.7753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R367Q	TCGA-A6-2686	COAD	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	0.6218
p.R362H	TCGA-AX-A1C9	UCEC	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	0.8244
p.R367L	TCGA-B5-A1MX	UCEC	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	0.7316
p.G370E	TCGA-DK-A3X1	BLCA	TCGA	LRWDLPRVQ	DEG_APCC_DBOX_1	0.3056
p.G377E	DO447	BLCA	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.1111
p.R374Q	DO7828	COAD	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.1944
p.R374Q	SIDM01079	Melanoma	GDSC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.1944
p.L361P	DO223157	ESCA	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.6471
p.E353K	DO51761	STAD	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.5556
p.R369H	DO43098	UCEC	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.8244
p.R374L	DO41999	UCEC	ICGC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.1944
p.A361P	SIDM00791	Chronic Myelogenous Leukemia	GDSC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.7503
p.A361P	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.7503
p.R374W	SIDM00209	Glioblastoma	GDSC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.1944
p.R374W	D-423MG	central_nervous_system	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.1944
p.R367W	ACH-002228	Brain Cancer	CCLE	LRWDLPRVQ	DEG_APCC_DBOX_1	0.7523
p.R367W	D-423MG	central_nervous_system	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.7523
p.A354P	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	LRWDLPRVQ	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00189	AP-4 complex subunit mu-1	DEG_APCC_DBOX_1	361:369	LRWDLPRVQ	APC,CDC20,FZR1	0.7918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons