DegronMD - O00192(ARVCF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G152D	TCGA-BR-8591	STAD	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.25
p.D160G	TCGA-CC-A7IH	LIHC	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.7198
p.R165Q	TCGA-CQ-A4CI	HNSC	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1944
p.R170C	TCGA-DF-A2KN	UCEC	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.0556
p.R170C	TCGA-QQ-A8VF	SARC	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.0556
p.R165W	TCGA-FP-A4BE	STAD	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1944
p.F167L	TCGA-FS-A1ZB	SKCM	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1389
p.A162T	TCGA-L5-A8NV	ESCA	TCGA	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.2778
p.P157L	DO229346	LAML	ICGC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.6471
p.P157L	DO230548	LUSC	ICGC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.6471
p.T165P	DO26540	LUSC	ICGC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1944
p.P154L	DO229502	SKCA	ICGC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.3056
p.D150N	SIDM00662	Melanoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1944
p.D150N	SIDM00985	Burkitt's Lymphoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1944
p.D150N	SIDM00731	Small Cell Lung Carcinoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1944
p.D150N	SIDM01517	Head and Neck Carcinoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1944
p.G151S	SIDM01113	Other Sarcomas	GDSC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.2222
p.G151S	ACH-000939	Sarcoma	CCLE	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.2222
p.G151S	SK-UT-1	soft tissue	COSMIC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.2222
p.P154Q	SIDM00335	Endometrial Carcinoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.3056
p.P154Q	ACH-000192	Endometrial/Uterine Cancer	CCLE	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.3056
p.P154Q	MFE-280	endometrium	COSMIC	LGPFAD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.3056

Kaplan plot for ARVCF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARVCF

UniProt ID: O00192

Entrez ID: 421

Protein name: Armadillo repeat protein deleted in velo-cardio-facial syndrome

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARVCF in