DegronMD

Uniprot ID: O00192

Source protein: Armadillo repeat protein deleted in velo-cardio-facial syndrome

Source gene: ARVCF

Class: LIG_APCC_ABBA_1

Location: 155:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9792

ASA_SCORE: 58.0167

COIL: 0.8465

CONS_SCORE: 0.373

DSS_SCORE: 0.3835

HELIX: 0.0788

FCONS_SCORE: 0.8838

RIG_SCORE: 0.7105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G152D	TCGA-BR-8591	STAD	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.25
p.D160G	TCGA-CC-A7IH	LIHC	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.7198
p.R165Q	TCGA-CQ-A4CI	HNSC	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.1944
p.R170C	TCGA-DF-A2KN	UCEC	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.0556
p.R170C	TCGA-QQ-A8VF	SARC	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.0556
p.R165W	TCGA-FP-A4BE	STAD	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.1944
p.F167L	TCGA-FS-A1ZB	SKCM	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.1389
p.A162T	TCGA-L5-A8NV	ESCA	TCGA	LGPFAD	LIG_APCC_ABBA_1	0.2778
p.P157L	DO229346	LAML	ICGC	LGPFAD	LIG_APCC_ABBA_1	0.6471
p.P157L	DO230548	LUSC	ICGC	LGPFAD	LIG_APCC_ABBA_1	0.6471
p.T165P	DO26540	LUSC	ICGC	LGPFAD	LIG_APCC_ABBA_1	0.1944
p.P154L	DO229502	SKCA	ICGC	LGPFAD	LIG_APCC_ABBA_1	0.3056
p.D150N	SIDM00662	Melanoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	0.1944
p.D150N	SIDM00985	Burkitt's Lymphoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	0.1944
p.D150N	SIDM00731	Small Cell Lung Carcinoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	0.1944
p.D150N	SIDM01517	Head and Neck Carcinoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	0.1944
p.G151S	SIDM01113	Other Sarcomas	GDSC	LGPFAD	LIG_APCC_ABBA_1	0.2222
p.G151S	ACH-000939	Sarcoma	CCLE	LGPFAD	LIG_APCC_ABBA_1	0.2222
p.G151S	SK-UT-1	soft_tissue	COSMIC	LGPFAD	LIG_APCC_ABBA_1	0.2222
p.P154Q	SIDM00335	Endometrial Carcinoma	GDSC	LGPFAD	LIG_APCC_ABBA_1	0.3056
p.P154Q	ACH-000192	Endometrial/Uterine Cancer	CCLE	LGPFAD	LIG_APCC_ABBA_1	0.3056
p.P154Q	MFE-280	endometrium	COSMIC	LGPFAD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00192	Armadillo repeat protein deleted in velo-cardio-facial syndrome	LIG_APCC_ABBA_1	155:160	LGPFAD	APC,CDC20,FZR1	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons