DegronMD - O00212(RHOD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M159I	TCGA-06-5416	GBM	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1389
p.M159I	DO10880	GBM	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1389
p.A160T	TCGA-2W-A8YY	CESC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1111
p.A160T	DO223732	CESC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1111
p.K135R	TCGA-A5-A0G1	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation substituting flanking lysine	0.1944
p.K135R	DO42472	UCEC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation substituting flanking lysine	0.1944
p.H154P	TCGA-A5-A0G2	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2778
p.H154P	DO41235	UCEC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2778
p.D136G	TCGA-AX-A0J1	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1111
p.G156S	TCGA-EE-A29V	SKCM	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2222
p.G156S	DO38006	SKCM	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2222
p.H154N	TCGA-EE-A2GH	SKCM	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2778
p.H154N	DO37643	SKCM	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2778
p.S162F	TCGA-EO-A22U	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.0556
p.S162F	DO43755	UCEC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.0556
p.R135L	DO228985	LICA	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation substituting flanking lysine	0.1944
p.K142M	ACH-000837	Lung Cancer	CCLE	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2778
p.Q138R	OC-314	ovary	COSMIC	RRNGLEPVT	DEG_APCC_DBOX_1	144:152	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for RHOD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHOD

UniProt ID: O00212

Entrez ID: 29984

Protein name: Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RHOD in