DegronMD

Uniprot ID: O00212

Source protein: Rho-related GTP-binding protein RhoD

Source gene: RHOD

Class: DEG_APCC_DBOX_1

Location: 144:152

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9269

ASA_SCORE: 83.6667

COIL: 0.7779

CONS_SCORE: 0.8877

DSS_SCORE: 0.3713

HELIX: 0.199

FCONS_SCORE: 0.9982

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M159I	TCGA-06-5416	GBM	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.1389
p.M159I	DO10880	GBM	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.1389
p.A160T	TCGA-2W-A8YY	CESC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.1111
p.A160T	DO223732	CESC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.1111
p.K135R	TCGA-A5-A0G1	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.1944
p.K135R	DO42472	UCEC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.1944
p.H154P	TCGA-A5-A0G2	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.2778
p.H154P	DO41235	UCEC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.2778
p.D136G	TCGA-AX-A0J1	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.1111
p.G156S	TCGA-EE-A29V	SKCM	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.2222
p.G156S	DO38006	SKCM	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.2222
p.H154N	TCGA-EE-A2GH	SKCM	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.2778
p.H154N	DO37643	SKCM	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.2778
p.S162F	TCGA-EO-A22U	UCEC	TCGA	RRNGLEPVT	DEG_APCC_DBOX_1	0.0556
p.S162F	DO43755	UCEC	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.0556
p.R135L	DO228985	LICA	ICGC	RRNGLEPVT	DEG_APCC_DBOX_1	0.1944
p.K142M	ACH-000837	Lung Cancer	CCLE	RRNGLEPVT	DEG_APCC_DBOX_1	0.2778
p.Q138R	OC-314	ovary	COSMIC	RRNGLEPVT	DEG_APCC_DBOX_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00212	Rho-related GTP-binding protein RhoD	DEG_APCC_DBOX_1	144:152	RRNGLEPVT	APC,CDC20,FZR1	0.9269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons