DegronMD - O00267(SUPT5H)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S763A	TCGA-A8-A08R	BRCA	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.0833
p.S763A	DO1255	BRCA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.0833
p.R757H	TCGA-BR-A4QL	STAD	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.25
p.R757H	DO38723	STAD	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.25
p.R756Q	TCGA-D8-A1XQ	BRCA	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.2778
p.R756Q	DO3095	BRCA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.2778
p.S738F	TCGA-EE-A2MN	SKCM	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1111
p.S738F	DO222438	MELA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1111
p.S738F	DO37423	SKCM	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1111
p.T762I	TCGA-FW-A3R5	SKCM	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation blocking phosphorylation signal	0.5556
p.T762I	DO37406	SKCM	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation blocking phosphorylation signal	0.5556
p.R747S	DO227996	COCA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.7427
p.R747S	SIDM00498	Colorectal Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.7427
p.R747S	ACH-000970	Colon/Colorectal Cancer	CCLE	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.7427
p.R747S	SNU-C5	large intestine	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.7427
p.G760S	DO234198	ESAD	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1667
p.G754D	DO233817	GACA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.6087
p.M761I	DO229019	LICA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1389
p.M761I	DO229008	LICA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1389
p.M761I	SIDM00617	Hepatocellular Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1389
p.M761I	ACH-000577	Liver Cancer	CCLE	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1389
p.M761I	JHH-2	liver	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.1389
p.R749W	DO23344	LINC	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.7523
p.V753M	SIDM01174	Cervical Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.6097
p.V753M	SW756	cervix	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.6097
p.R757C	SIDM00654	Small Cell Lung Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.25
p.R757C	ACH-000866	Lung Cancer	CCLE	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.25
p.V749M	SW756	cervix	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation altering degron motif	0.7208
p.R743S	SNU-C5	large intestine	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.25
p.M757I	JHH-2	liver	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	746:754	Mutation rewiring degron network	0.25

Kaplan plot for SUPT5H in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUPT5H

UniProt ID: O00267

Entrez ID: 6829

Protein name: Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUPT5H in