DegronMD

Uniprot ID: O00267

Source protein: Transcription elongation factor SPT5

Source gene: SUPT5H

Class: DEG_APCC_DBOX_1

Location: 746:754

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7696

ASA_SCORE: 71.3111

COIL: 0.3932

CONS_SCORE: 0.3315

DSS_SCORE: 0.5646

HELIX: 0.237

FCONS_SCORE: 0.8291

RIG_SCORE: 0.779

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S763A	TCGA-A8-A08R	BRCA	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	0.0833
p.S763A	DO1255	BRCA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.0833
p.R757H	TCGA-BR-A4QL	STAD	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	0.25
p.R757H	DO38723	STAD	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.25
p.R756Q	TCGA-D8-A1XQ	BRCA	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	0.2778
p.R756Q	DO3095	BRCA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.2778
p.S738F	TCGA-EE-A2MN	SKCM	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	0.1111
p.S738F	DO222438	MELA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.1111
p.S738F	DO37423	SKCM	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.1111
p.T762I	TCGA-FW-A3R5	SKCM	TCGA	DRQRLTTVG	DEG_APCC_DBOX_1	0.5556
p.T762I	DO37406	SKCM	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.5556
p.R747S	DO227996	COCA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.7427
p.R747S	SIDM00498	Colorectal Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	0.7427
p.R747S	ACH-000970	Colon/Colorectal Cancer	CCLE	DRQRLTTVG	DEG_APCC_DBOX_1	0.7427
p.R747S	SNU-C5	large_intestine	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	0.7427
p.G760S	DO234198	ESAD	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.1667
p.G754D	DO233817	GACA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.6087
p.M761I	DO229019	LICA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.1389
p.M761I	DO229008	LICA	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.1389
p.M761I	SIDM00617	Hepatocellular Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	0.1389
p.M761I	ACH-000577	Liver Cancer	CCLE	DRQRLTTVG	DEG_APCC_DBOX_1	0.1389
p.M761I	JHH-2	liver	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	0.1389
p.R749W	DO23344	LINC	ICGC	DRQRLTTVG	DEG_APCC_DBOX_1	0.7523
p.V753M	SIDM01174	Cervical Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	0.6097
p.V753M	SW756	cervix	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	0.6097
p.R757C	SIDM00654	Small Cell Lung Carcinoma	GDSC	DRQRLTTVG	DEG_APCC_DBOX_1	0.25
p.R757C	ACH-000866	Lung Cancer	CCLE	DRQRLTTVG	DEG_APCC_DBOX_1	0.25
p.V749M	SW756	cervix	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	0.7208
p.R743S	SNU-C5	large_intestine	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	0.25
p.M757I	JHH-2	liver	COSMIC	DRQRLTTVG	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRQRLTTVG

Degron related mutations and impact score

Drug responses associated with SUPT5H mutations

All proteins holding degron of DRQRLTTVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00267	Transcription elongation factor SPT5	DEG_APCC_DBOX_1	746:754	DRQRLTTVG	APC,CDC20,FZR1	0.7696	More...