DegronMD - O00287(RFXAP)

RFXAP

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q181H	TCGA-AX-A2HD	UCEC	TCGA	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.0833
p.Q181H	DO42608	UCEC	ICGC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.0833
p.K175T	TCGA-CA-6717	COAD	TCGA	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation substituting flanking lysine	0.3611
p.K175T	DO8264	COAD	ICGC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation substituting flanking lysine	0.3611
p.K176N	DO48320	ESCA	ICGC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation substituting flanking lysine	0.3333
p.K163N	SIDM01286	Esophageal Carcinoma	GDSC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation substituting flanking lysine	0.3611
p.H165R	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.3056
p.H165R	ACH-000914	Lymphoma	CCLE	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.3056
p.H165R	HT	haematopoietic and lymphoid tissue	COSMIC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.3056
p.M161L	SIDM00537	Colorectal Carcinoma	GDSC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.1944
p.M161L	ACH-000982	Colon/Colorectal Cancer	CCLE	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.1944
p.M161L	ACH-001345	Colon/Colorectal Cancer	CCLE	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.1944
p.M161L	GP5d	large intestine	COSMIC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	166:172	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc