DegronMD

Uniprot ID: O00287

Source protein: Regulatory factor X-associated protein

Source gene: RFXAP

Class: LIG_APCC_ABBAyCdc20_2

Location: 166:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9506

ASA_SCORE: 115.0714

COIL: 0.5611

CONS_SCORE: 1

DSS_SCORE: 0.4614

HELIX: 0.4254

FCONS_SCORE: 1.0783

RIG_SCORE: 0.794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q181H	TCGA-AX-A2HD	UCEC	TCGA	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q181H	DO42608	UCEC	ICGC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K175T	TCGA-CA-6717	COAD	TCGA	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.3611
p.K175T	DO8264	COAD	ICGC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.3611
p.K176N	DO48320	ESCA	ICGC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.3333
p.K163N	SIDM01286	Esophageal Carcinoma	GDSC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.3611
p.H165R	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H165R	ACH-000914	Lymphoma	CCLE	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H165R	HT	haematopoietic_and_lymphoid_tissue	COSMIC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M161L	SIDM00537	Colorectal Carcinoma	GDSC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M161L	ACH-000982	Colon/Colorectal Cancer	CCLE	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M161L	ACH-001345	Colon/Colorectal Cancer	CCLE	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M161L	GP5d	large_intestine	COSMIC	RNKMYKD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00287	Regulatory factor X-associated protein	LIG_APCC_ABBAyCdc20_2	166:172	RNKMYKD	APC,CDC20,FZR1	0.9506	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons