DegronMD - O00291(HIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q451L	TCGA-09-2053	OV	TCGA	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0556
p.Q451L	DO31060	OV	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0556
p.D429E	TCGA-A5-A1OF	UCEC	TCGA	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2222
p.D429E	DO42568	UCEC	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.2222
p.R442S	TCGA-A6-5657	COAD	TCGA	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.3056
p.R442S	DO10459	COAD	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.3056
p.Q424K	TCGA-AA-3489	COAD	TCGA	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0833
p.Q424K	DO10702	COAD	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.0833
p.A426E	TCGA-ER-A19P	SKCM	TCGA	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1389
p.A426E	DO229035	LICA	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1389
p.A426E	DO47623	SKCM	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1389
p.R441M	TCGA-HU-A4H3	STAD	TCGA	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.7521
p.R441M	DO47903	STAD	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.7521
p.T447S	DO228921	LICA	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.1667
p.R434W	DO50732	ORCA	ICGC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation altering degron motif	0.8634
p.R444Q	SIDM00217	Colorectal Carcinoma	GDSC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25
p.R444Q	ACH-000999	Colon/Colorectal Cancer	CCLE	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25
p.R444Q	SNU-1040	large intestine	COSMIC	LRAELDELR	DEG_APCC_DBOX_1	433:441	Mutation rewiring degron network	0.25

Kaplan plot for HIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIP1

UniProt ID: O00291

Entrez ID: 3092

Protein name: Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HIP1 in