DegronMD

Uniprot ID: O00291

Source protein: Huntingtin-interacting protein 1

Source gene: HIP1

Class: DEG_APCC_DBOX_1

Location: 433:441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7108

ASA_SCORE: 97.6444

COIL: 0.03

CONS_SCORE: 0.4458

DSS_SCORE: 0.3766

HELIX: 0.97

FCONS_SCORE: 1.1847

RIG_SCORE: 0.7922

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q451L	TCGA-09-2053	OV	TCGA	LRAELDELR	DEG_APCC_DBOX_1	0.0556
p.Q451L	DO31060	OV	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.0556
p.D429E	TCGA-A5-A1OF	UCEC	TCGA	LRAELDELR	DEG_APCC_DBOX_1	0.2222
p.D429E	DO42568	UCEC	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.2222
p.R442S	TCGA-A6-5657	COAD	TCGA	LRAELDELR	DEG_APCC_DBOX_1	0.3056
p.R442S	DO10459	COAD	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.3056
p.Q424K	TCGA-AA-3489	COAD	TCGA	LRAELDELR	DEG_APCC_DBOX_1	0.0833
p.Q424K	DO10702	COAD	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.0833
p.A426E	TCGA-ER-A19P	SKCM	TCGA	LRAELDELR	DEG_APCC_DBOX_1	0.1389
p.A426E	DO229035	LICA	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.1389
p.A426E	DO47623	SKCM	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.1389
p.R441M	TCGA-HU-A4H3	STAD	TCGA	LRAELDELR	DEG_APCC_DBOX_1	0.7521
p.R441M	DO47903	STAD	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.7521
p.T447S	DO228921	LICA	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.1667
p.R434W	DO50732	ORCA	ICGC	LRAELDELR	DEG_APCC_DBOX_1	0.8634
p.R444Q	SIDM00217	Colorectal Carcinoma	GDSC	LRAELDELR	DEG_APCC_DBOX_1	0.25
p.R444Q	ACH-000999	Colon/Colorectal Cancer	CCLE	LRAELDELR	DEG_APCC_DBOX_1	0.25
p.R444Q	SNU-1040	large_intestine	COSMIC	LRAELDELR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00291	Huntingtin-interacting protein 1	DEG_APCC_DBOX_1	433:441	LRAELDELR	APC,CDC20,FZR1	0.7108	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons