DegronMD - O00295(TULP2)

GO - Biological processes (BP): protein localization to cilium [GO:0061512]; visual perception [GO:0007601]

GO - Molecular function (MF): protein-containing complex binding [GO:0044877]

GO - Cellular component (CC): cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LPTPRTE	DEG_SCF_FBW7_2	FBXW7	Tubby-related protein 2	109:115	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P112L	TCGA-06-5416	GBM	TCGA	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.7582
p.P112L	TCGA-GM-A2DN	BRCA	TCGA	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.7582
p.P112L	DO2305	BRCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.7582
p.P112L	DO10880	GBM	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.7582
p.R113W	DO222984	BTCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.7523
p.R113W	DO229373	BTCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.7523
p.T114K	TCGA-AA-3811	COAD	TCGA	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.6195
p.T114K	DO7962	COAD	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.6195
p.P110Q	DO35561	PBCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation altering degron motif	0.5924
p.G108S	TCGA-CN-4735	HNSC	TCGA	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation rewiring degron network	0.3056
p.G108S	DO14172	HNSC	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation rewiring degron network	0.3056
p.L121I	TCGA-BS-A0UF	UCEC	TCGA	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation rewiring degron network	0.1667
p.L121I	DO41488	UCEC	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation rewiring degron network	0.1667
p.G103C	ACH-001419	Breast Cancer	CCLE	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation rewiring degron network	0.1667
p.L123F	DO228948	LICA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation rewiring degron network	0.1111
p.L123I	SIDM01293	Colorectal Carcinoma	GDSC	LPTPRTE	DEG_SCF_FBW7_2	109:115	Mutation rewiring degron network	0.1111

Showing 1 to 16 of 16 entries

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No resistance data available for this Degron.

Kaplan plot for TULP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TULP2

UniProt ID: O00295

Entrez ID: 7288

Protein name: Tubby-related protein 2 (Cancer/testis antigen 65) (CT65) (Tubby-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for TULP2 in