DegronMD

Uniprot ID: O00295

Source protein: Tubby-related protein 2

Source gene: TULP2

Class: DEG_SCF_FBW7_2

Location: 109:115

E3 ligase: FBXW7

DEGRON score: 0.9041

ASA_SCORE: 82.2286

COIL: 0.7004

CONS_SCORE: 0.324

DSS_SCORE: 0.5286

HELIX: 0.2481

FCONS_SCORE: 1.0011

RIG_SCORE: 0.7499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P112L	TCGA-06-5416	GBM	TCGA	LPTPRTE	DEG_SCF_FBW7_2	0.7582
p.P112L	TCGA-GM-A2DN	BRCA	TCGA	LPTPRTE	DEG_SCF_FBW7_2	0.7582
p.P112L	DO2305	BRCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.7582
p.P112L	DO10880	GBM	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.7582
p.T114K	TCGA-AA-3811	COAD	TCGA	LPTPRTE	DEG_SCF_FBW7_2	0.6195
p.T114K	DO7962	COAD	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.6195
p.L121I	TCGA-BS-A0UF	UCEC	TCGA	LPTPRTE	DEG_SCF_FBW7_2	0.1667
p.L121I	DO41488	UCEC	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.1667
p.G108S	TCGA-CN-4735	HNSC	TCGA	LPTPRTE	DEG_SCF_FBW7_2	0.3056
p.G108S	DO14172	HNSC	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.3056
p.R113W	DO222984	BTCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.7523
p.R113W	DO229373	BTCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.7523
p.L123F	DO228948	LICA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.1111
p.P110Q	DO35561	PBCA	ICGC	LPTPRTE	DEG_SCF_FBW7_2	0.5924
p.L123I	SIDM01293	Colorectal Carcinoma	GDSC	LPTPRTE	DEG_SCF_FBW7_2	0.1111
p.G103C	ACH-001419	Breast Cancer	CCLE	LPTPRTE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00295	Tubby-related protein 2	DEG_SCF_FBW7_2	109:115	LPTPRTE	FBXW7	0.9041	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons