DegronMD - O00330(PDHX)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T229N	TCGA-17-Z031	LUAD	TCGA	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.2222
p.T225K	TCGA-24-1417	OV	TCGA	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.1111
p.E230K	TCGA-CR-7364	HNSC	TCGA	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.25
p.K227R	TCGA-HU-A4GH	STAD	TCGA	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation substituting flanking lysine	0.2778
p.T238I	TCGA-JW-A5VL	CESC	TCGA	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation altering degron motif	0.7078
p.T223I	DO49976	CESC	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation blocking ubiquitination signal	0.5
p.R242W	DO10244	COAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.2222
p.R242W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.2222
p.P243H	DO230323	COCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.1944
p.T225I	DO234407	ESAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.1111
p.R242Q	DO233101	GACA	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.2222
p.P246L	DO15903	HNSC	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.1111
p.A234S	DO229038	LICA	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation altering degron motif	0.7588
p.P243S	DO27088	LUSC	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.1944
p.P241S	DO220882	MELA	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.25
p.T223P	DO219881	SKCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation blocking ubiquitination signal	0.5
p.K227Q	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation substituting flanking lysine	0.2778
p.K227Q	ACH-000438	Lung Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation substituting flanking lysine	0.2778
p.K227Q	LU-65	lung	COSMIC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation substituting flanking lysine	0.2778
p.S245L	SIDM01608	Endometrial Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.1389
p.P237T	SIDM01592	Breast Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation altering degron motif	0.5919
p.R242L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.2222
p.V248A	AN3-CA	endometrium	COSMIC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.0556
p.K233N	DB	haematopoietic and lymphoid tissue	COSMIC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation altering degron motif	0.6918
p.P243L	SNU-1040	large intestine	COSMIC	PTPAPT	DEG_SCF_FBW7_1	233:238	Mutation rewiring degron network	0.1944

Kaplan plot for PDHX in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDHX

UniProt ID: O00330

Entrez ID: 8050

Protein name: Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PDHX in