DegronMD

Uniprot ID: O00330

Source protein: Pyruvate dehydrogenase protein X component, mitochondrial

Source gene: PDHX

Class: DEG_SCF_FBW7_1

Location: 233:238

E3 ligase: FBXW7

DEGRON score: 0.9254

ASA_SCORE: 90.55

COIL: 0.9622

CONS_SCORE: 0.2811

DSS_SCORE: 0.7419

HELIX: 0.0125

FCONS_SCORE: 1.0465

RIG_SCORE: 0.6005

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T229N	TCGA-17-Z031	LUAD	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.2222
p.T225K	TCGA-24-1417	OV	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.1111
p.E230K	TCGA-CR-7364	HNSC	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.25
p.K227R	TCGA-HU-A4GH	STAD	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.T238I	TCGA-JW-A5VL	CESC	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.7078
p.T223I	DO49976	CESC	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.5
p.R242W	DO10244	COAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.2222
p.R242W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.2222
p.P243H	DO230323	COCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.T225I	DO234407	ESAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1111
p.R242Q	DO233101	GACA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.2222
p.P246L	DO15903	HNSC	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1111
p.A234S	DO229038	LICA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.7588
p.P243S	DO27088	LUSC	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.P241S	DO220882	MELA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.25
p.T223P	DO219881	SKCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.5
p.K227Q	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.K227Q	ACH-000438	Lung Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.K227Q	LU-65	lung	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.S245L	SIDM01608	Endometrial Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	0.1389
p.P237T	SIDM01592	Breast Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	0.5919
p.R242L	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.2222
p.V248A	AN3-CA	endometrium	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.0556
p.K233N	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.6918
p.P243L	SNU-1040	large_intestine	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00330	Pyruvate dehydrogenase protein X component, mitochondrial	DEG_SCF_FBW7_1	233:238	PTPAPT	FBXW7	0.9254	More...
Q03014	Hematopoietically-expressed homeobox protein HHEX	DEG_SCF_FBW7_1	45:50	PTPAPT	FBXW7	0.9307	More...
Q6ZNJ1	Neurobeachin-like protein 2	DEG_SCF_FBW7_1	618:623	PTPAPT	FBXW7	0.8692	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons