DegronMD - Q6ZNJ1(NBEAL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A617V	TCGA-22-1016	LUSC	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.3056
p.A617V	DO26971	LUSC	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.3056
p.Q2016R	TCGA-22-4591	LUSC	TCGA	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation rewiring degron network	0.25
p.R1826C	TCGA-75-5126	LUAD	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation rewiring degron network	0.0556
p.L1852P	TCGA-AM-5821	COAD	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation rewiring degron network	0.1111
p.L1852P	TCGA-AM-5821	COAD	TCGA	LRDNLGEVP	DEG_APCC_DBOX_1	1857:1865	Mutation rewiring degron network	0.1944
p.H612R	TCGA-AP-A1DK	UCEC	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1667
p.H612R	DO42033	UCEC	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1667
p.H612R	ACH-002179	Breast Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1667
p.H612R	OCUB-M	breast	COSMIC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1667
p.P613H	TCGA-BF-A1PU	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1944
p.P613H	TCGA-FS-A1ZG	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1944
p.P613H	DO37523	SKCM	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1944
p.P613H	DO50278	SKCM	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1944
p.A617T	TCGA-BR-6452	STAD	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.3056
p.A617T	DO38404	STAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.3056
p.T619A	TCGA-C5-A7CG	CESC	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation altering degron motif	0.7139
p.R1839H	TCGA-CK-4951	COAD	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation altering degron motif	0.7133
p.R1839H	TCGA-DU-6392	LGG	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation altering degron motif	0.7133
p.R1826H	TCGA-CQ-5323	HNSC	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation rewiring degron network	0.0556
p.R1826H	ACH-000999	Colon/Colorectal Cancer	CCLE	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation rewiring degron network	0.0556
p.P625L	TCGA-D9-A6EC	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.2778
p.P625L	DO50291	SKCM	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.2778
p.W1827C	TCGA-DK-A2I1	BLCA	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation rewiring degron network	0.0833
p.E1870D	TCGA-DK-A2I1	BLCA	TCGA	VPLTPTEE	DEG_SCF_FBW7_2	1864:1871	Mutation altering degron motif	0.5647
p.P613L	TCGA-DU-6392	LGG	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1944
p.P613L	DO22237	LGG	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.1944
p.R1839C	TCGA-EA-A410	CESC	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation altering degron motif	0.719
p.R1826S	TCGA-EE-A2MG	SKCM	TCGA	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation rewiring degron network	0.0556
p.P620H	TCGA-FS-A1ZJ	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation altering degron motif	0.7694
p.P2010S	TCGA-GN-A8LK	SKCM	TCGA	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation altering degron motif	0.6752
p.R1858Q	TCGA-YD-A9TA	SKCM	TCGA	LRDNLGEVP	DEG_APCC_DBOX_1	1857:1865	Mutation altering degron motif	0.7329
p.T619I	DO225280	BRCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation altering degron motif	0.7078
p.K618R	DO8682	COAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation altering degron motif	0.7237
p.R624Q	DO233764	GACA	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.3056
p.R633C	DO44575	LGG	ICGC	PTPAPT	DEG_SCF_FBW7_1	618:623	Mutation rewiring degron network	0.0556
p.T2008M	SIDM00517	Head and Neck Carcinoma	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation altering degron motif	0.7423
p.T2008M	SIDM01009	Neuroblastoma	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation altering degron motif	0.7423
p.P2022T	SIDM01218	Other Solid Cancers	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation rewiring degron network	0.0833
p.P2022T	ACH-001530	Endometrial/Uterine Cancer	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation rewiring degron network	0.0833
p.P2022T	JEG-3	placenta	COSMIC	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation rewiring degron network	0.0833
p.S1831R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation blocking phosphorylation signal	0.6389
p.S1831R	ACH-000451	Lung Cancer	CCLE	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation blocking phosphorylation signal	0.6389
p.S1831R	NCI-H2085	lung	COSMIC	SRMRLKLVP	DEG_APCC_DBOX_1	1836:1844	Mutation blocking phosphorylation signal	0.6389
p.Y1998N	SIDM01735	Biliary Tract Carcinoma	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation rewiring degron network	0.1111
p.Y1998N	ACH-000808	Bile Duct Cancer	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation rewiring degron network	0.1111
p.V1864A	ACH-000179	Lung Cancer	CCLE	LRDNLGEVP	DEG_APCC_DBOX_1	1857:1865	Mutation altering degron motif	0.6936
p.V1864A	ACH-000179	Lung Cancer	CCLE	VPLTPTEE	DEG_SCF_FBW7_2	1864:1871	Mutation altering degron motif	0.6936
p.N1997S	ACH-001751	Sarcoma	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation rewiring degron network	0.0833
p.T2008K	ACH-001992	Primary	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	2006:2013	Mutation altering degron motif	0.7306

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NBEAL2

UniProt ID: Q6ZNJ1

Entrez ID: 23218

Protein name: Neurobeachin-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NBEAL2 in