DegronMD

Uniprot ID: Q6ZNJ1

Source protein: Neurobeachin-like protein 2

Source gene: NBEAL2

Class: DEG_SCF_FBW7_1

Location: 2006:2013

E3 ligase: FBXW7

DEGRON score: 0.9635

ASA_SCORE: 55.4625

COIL: 0.6954

CONS_SCORE: 0.058

DSS_SCORE: 0.4676

HELIX: 0.0573

FCONS_SCORE: 0.2299

RIG_SCORE: 0.6633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2016R	TCGA-22-4591	LUSC	TCGA	VGTTPVSS	DEG_SCF_FBW7_1	0.25
p.P2010S	TCGA-GN-A8LK	SKCM	TCGA	VGTTPVSS	DEG_SCF_FBW7_1	0.6752
p.T2008M	SIDM00517	Head and Neck Carcinoma	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	0.7423
p.T2008M	SIDM01009	Neuroblastoma	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	0.7423
p.P2022T	SIDM01218	Other Solid Cancers	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	0.0833
p.P2022T	ACH-001530	Endometrial/Uterine Cancer	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	0.0833
p.P2022T	JEG-3	placenta	COSMIC	VGTTPVSS	DEG_SCF_FBW7_1	0.0833
p.Y1998N	SIDM01735	Biliary Tract Carcinoma	GDSC	VGTTPVSS	DEG_SCF_FBW7_1	0.1111
p.Y1998N	ACH-000808	Bile Duct Cancer	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	0.1111
p.N1997S	ACH-001751	Sarcoma	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	0.0833
p.T2008K	ACH-001992	Primary	CCLE	VGTTPVSS	DEG_SCF_FBW7_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNJ1	Neurobeachin-like protein 2	DEG_SCF_FBW7_1	2006:2013	VGTTPVSS	FBXW7	0.9635	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons