DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRMRLKLVP
Uniprot ID:
Q6ZNJ1
Source protein:
Neurobeachin-like protein 2
Source gene:
NBEAL2
Class:
DEG_APCC_DBOX_1
Location:
1836:1844
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7348
ASA_SCORE:
76.3889
COIL:
0.5977
CONS_SCORE:
0.3972
DSS_SCORE:
0.273
HELIX:
0.0802
FCONS_SCORE:
1.097
RIG_SCORE:
0.7403
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1826C
TCGA-75-5126
LUAD
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.0556
p.L1852P
TCGA-AM-5821
COAD
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.1111
p.R1839H
TCGA-CK-4951
COAD
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.7133
p.R1839H
TCGA-DU-6392
LGG
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.7133
p.R1826H
TCGA-CQ-5323
HNSC
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.0556
p.R1826H
ACH-000999
Colon/Colorectal Cancer
CCLE
SRMRLKLVP
DEG_APCC_DBOX_1
0.0556
p.W1827C
TCGA-DK-A2I1
BLCA
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.0833
p.R1839C
TCGA-EA-A410
CESC
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.719
p.R1826S
TCGA-EE-A2MG
SKCM
TCGA
SRMRLKLVP
DEG_APCC_DBOX_1
0.0556
p.S1831R
SIDM00709
Non-Small Cell Lung Carcinoma
GDSC
SRMRLKLVP
DEG_APCC_DBOX_1
0.6389
p.S1831R
ACH-000451
Lung Cancer
CCLE
SRMRLKLVP
DEG_APCC_DBOX_1
0.6389
p.S1831R
NCI-H2085
lung
COSMIC
SRMRLKLVP
DEG_APCC_DBOX_1
0.6389
Drug responses associated with NBEAL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRMRLKLVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZNJ1
Neurobeachin-like protein 2
DEG_APCC_DBOX_1
1836:1844
SRMRLKLVP
APC,CDC20,FZR1
0.7348
More...