DegronMD

Uniprot ID: Q6ZNJ1

Source protein: Neurobeachin-like protein 2

Source gene: NBEAL2

Class: DEG_APCC_DBOX_1

Location: 1857:1865

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 85.8333

COIL: 0.7449

CONS_SCORE: 0.3686

DSS_SCORE: 0.4837

HELIX: 0.2117

FCONS_SCORE: 1.1473

RIG_SCORE: 0.6973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1852P	TCGA-AM-5821	COAD	TCGA	LRDNLGEVP	DEG_APCC_DBOX_1	0.1944
p.R1858Q	TCGA-YD-A9TA	SKCM	TCGA	LRDNLGEVP	DEG_APCC_DBOX_1	0.7329
p.V1864A	ACH-000179	Lung Cancer	CCLE	LRDNLGEVP	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNJ1	Neurobeachin-like protein 2	DEG_APCC_DBOX_1	1857:1865	LRDNLGEVP	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons