DegronMD

Uniprot ID: Q6ZNJ1

Source protein: Neurobeachin-like protein 2

Source gene: NBEAL2

Class: DEG_SCF_FBW7_1

Location: 618:623

E3 ligase: FBXW7

DEGRON score: 0.8692

ASA_SCORE: 81.6667

COIL: 0.9385

CONS_SCORE: 0.2515

DSS_SCORE: 0.4991

HELIX: 0.0203

FCONS_SCORE: 0.838

RIG_SCORE: 0.7235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A617V	TCGA-22-1016	LUSC	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.3056
p.A617V	DO26971	LUSC	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.3056
p.H612R	TCGA-AP-A1DK	UCEC	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.1667
p.H612R	DO42033	UCEC	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1667
p.H612R	ACH-002179	Breast Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	0.1667
p.H612R	OCUB-M	breast	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.1667
p.P613H	TCGA-BF-A1PU	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.P613H	TCGA-FS-A1ZG	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.P613H	DO37523	SKCM	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.P613H	DO50278	SKCM	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.A617T	TCGA-BR-6452	STAD	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.3056
p.A617T	DO38404	STAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.3056
p.T619A	TCGA-C5-A7CG	CESC	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.7139
p.P625L	TCGA-D9-A6EC	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.P625L	DO50291	SKCM	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.P613L	TCGA-DU-6392	LGG	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.P613L	DO22237	LGG	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.P620H	TCGA-FS-A1ZJ	SKCM	TCGA	PTPAPT	DEG_SCF_FBW7_1	0.7694
p.T619I	DO225280	BRCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.7078
p.K618R	DO8682	COAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.7237
p.R624Q	DO233764	GACA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.3056
p.R633C	DO44575	LGG	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00330	Pyruvate dehydrogenase protein X component, mitochondrial	DEG_SCF_FBW7_1	233:238	PTPAPT	FBXW7	0.9254	More...
Q03014	Hematopoietically-expressed homeobox protein HHEX	DEG_SCF_FBW7_1	45:50	PTPAPT	FBXW7	0.9307	More...
Q6ZNJ1	Neurobeachin-like protein 2	DEG_SCF_FBW7_1	618:623	PTPAPT	FBXW7	0.8692	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons