DegronMD - Q03014(HHEX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R66W	TCGA-CK-4951	COAD	TCGA	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation altering degron motif	0.7523
p.R66W	DO10582	COAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation altering degron motif	0.7523
p.C64F	DO50644	BOCA	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation altering degron motif	0.7108
p.P52T	DO1002	BRCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.2778
p.S79P	DO8264	COAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.1111
p.D48H	DO222688	ESCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation altering degron motif	0.7688
p.L36V	DO16597	KIRC	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.0833
p.A48S	DO229027	LICA	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation altering degron motif	0.6477
p.D60Y	DO229008	LICA	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.0556
p.D60Y	DO229008	LICA	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.2222
p.P66L	DO50893	LICA	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation altering degron motif	0.7582
p.E77D	DO48732	LIRI	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.1667
p.E77D	DO41644	UCEC	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.1667
p.E35D	DO228355	MALY	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.0556
p.P52S	DO228355	MALY	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.2778
p.P77A	DO228355	MALY	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.1667
p.P47S	DO228587	MALY	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation altering degron motif	0.6752
p.E35K	DO222702	MELA	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.0556
p.I78V	DO32596	OV	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.1389
p.Q63H	DO223663	PRAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.3056
p.G56C	DO51761	STAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.1667
p.G56C	DO51761	STAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.1111
p.E37K	DO41379	UCEC	ICGC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.1111
p.S60C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.0556
p.S60C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.2222
p.S60C	ACH-000924	Lung Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.0556
p.S60C	ACH-000924	Lung Cancer	CCLE	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.2222
p.T73R	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PYRTPVYE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.2778
p.R40H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.1944
p.S51G	ACH-000969	Colon/Colorectal Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.3056
p.S51G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.3056
p.S51G	KM12	large intestine	COSMIC	PTPAPT	DEG_SCF_FBW7_1	45:50	Mutation rewiring degron network	0.3056

Kaplan plot for HHEX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HHEX

UniProt ID: Q03014

Entrez ID: 3087

Protein name: Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HHEX in