DegronMD

Uniprot ID: Q03014

Source protein: Hematopoietically-expressed homeobox protein HHEX

Source gene: HHEX

Class: DEG_SCF_FBW7_2

Location: 64:71

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 51.275

COIL: 0.8891

CONS_SCORE: 0.6205

DSS_SCORE: 0.3669

HELIX: 0.0495

FCONS_SCORE: 1.2777

RIG_SCORE: 0.7115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R66W	TCGA-CK-4951	COAD	TCGA	PYRTPVYE	DEG_SCF_FBW7_2	0.7523
p.R66W	DO10582	COAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.7523
p.C64F	DO50644	BOCA	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.7108
p.S79P	DO8264	COAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.1111
p.D60Y	DO229008	LICA	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.2222
p.P66L	DO50893	LICA	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.7582
p.E77D	DO48732	LIRI	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.1667
p.E77D	DO41644	UCEC	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.1667
p.P77A	DO228355	MALY	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.1667
p.I78V	DO32596	OV	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.1389
p.Q63H	DO223663	PRAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.3056
p.G56C	DO51761	STAD	ICGC	PYRTPVYE	DEG_SCF_FBW7_2	0.1111
p.S60C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PYRTPVYE	DEG_SCF_FBW7_2	0.2222
p.S60C	ACH-000924	Lung Cancer	CCLE	PYRTPVYE	DEG_SCF_FBW7_2	0.2222
p.T73R	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PYRTPVYE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03014	Hematopoietically-expressed homeobox protein HHEX	DEG_SCF_FBW7_2	64:71	PYRTPVYE	FBXW7	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons