DegronMD

Uniprot ID: Q03014

Source protein: Hematopoietically-expressed homeobox protein HHEX

Source gene: HHEX

Class: DEG_SCF_FBW7_1

Location: 45:50

E3 ligase: FBXW7

DEGRON score: 0.9307

ASA_SCORE: 88.2667

COIL: 0.9635

CONS_SCORE: 0.4162

DSS_SCORE: 0.6043

HELIX: 0.015

FCONS_SCORE: 0.8049

RIG_SCORE: 0.6205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P52T	DO1002	BRCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.D48H	DO222688	ESCA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.7688
p.L36V	DO16597	KIRC	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.0833
p.A48S	DO229027	LICA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.6477
p.D60Y	DO229008	LICA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.0556
p.E35D	DO228355	MALY	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.0556
p.P52S	DO228355	MALY	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.2778
p.P47S	DO228587	MALY	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.6752
p.E35K	DO222702	MELA	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.0556
p.G56C	DO51761	STAD	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1667
p.E37K	DO41379	UCEC	ICGC	PTPAPT	DEG_SCF_FBW7_1	0.1111
p.S60C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PTPAPT	DEG_SCF_FBW7_1	0.0556
p.S60C	ACH-000924	Lung Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	0.0556
p.R40H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	0.1944
p.S51G	ACH-000969	Colon/Colorectal Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	0.3056
p.S51G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPAPT	DEG_SCF_FBW7_1	0.3056
p.S51G	KM12	large_intestine	COSMIC	PTPAPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00330	Pyruvate dehydrogenase protein X component, mitochondrial	DEG_SCF_FBW7_1	233:238	PTPAPT	FBXW7	0.9254	More...
Q03014	Hematopoietically-expressed homeobox protein HHEX	DEG_SCF_FBW7_1	45:50	PTPAPT	FBXW7	0.9307	More...
Q6ZNJ1	Neurobeachin-like protein 2	DEG_SCF_FBW7_1	618:623	PTPAPT	FBXW7	0.8692	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons