DegronMD - O00488(ZNF593)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M19I	TCGA-B5-A5OC	UCEC	TCGA	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1944
p.M19I	DO52405	UCEC	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1944
p.E30D	TCGA-JX-A3Q0	CESC	TCGA	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.5647
p.E30D	DO51607	CESC	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.5647
p.A41T	DO227987	COCA	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0833
p.R17L	DO229037	LICA	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1389
p.R24W	DO229089	THCA	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.7523
p.R42P	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.R42P	ACH-000924	Lung Cancer	CCLE	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.D27E	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.5647
p.D27E	ACH-001638	Lymphoma	CCLE	RRPDLDEIH	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.5647

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons