DegronMD

Uniprot ID: O00488

Source protein: Zinc finger protein 593

Source gene: ZNF593

Class: DEG_APCC_DBOX_1

Location: 24:32

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9857

ASA_SCORE: 74.1444

COIL: 0.4143

CONS_SCORE: 0.6636

DSS_SCORE: 0.7396

HELIX: 0.5829

FCONS_SCORE: 1.3412

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M19I	TCGA-B5-A5OC	UCEC	TCGA	RRPDLDEIH	DEG_APCC_DBOX_1	0.1944
p.M19I	DO52405	UCEC	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	0.1944
p.E30D	TCGA-JX-A3Q0	CESC	TCGA	RRPDLDEIH	DEG_APCC_DBOX_1	0.5647
p.E30D	DO51607	CESC	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	0.5647
p.A41T	DO227987	COCA	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	0.0833
p.R17L	DO229037	LICA	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	0.1389
p.R24W	DO229089	THCA	ICGC	RRPDLDEIH	DEG_APCC_DBOX_1	0.7523
p.R42P	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RRPDLDEIH	DEG_APCC_DBOX_1	0.0556
p.R42P	ACH-000924	Lung Cancer	CCLE	RRPDLDEIH	DEG_APCC_DBOX_1	0.0556
p.D27E	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRPDLDEIH	DEG_APCC_DBOX_1	0.5647
p.D27E	ACH-001638	Lymphoma	CCLE	RRPDLDEIH	DEG_APCC_DBOX_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00488	Zinc finger protein 593	DEG_APCC_DBOX_1	24:32	RRPDLDEIH	APC,CDC20,FZR1	0.9857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons