DegronMD - O00533(CHL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G603S	TCGA-17-Z049	LUAD	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.3056
p.S595Y	TCGA-55-5899	LUAD	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.0833
p.S595Y	DO26042	LUAD	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.0833
p.S595Y	SIDM01588	Endometrial Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.0833
p.S595Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.0833
p.G603V	TCGA-56-7223	LUSC	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.3056
p.G603V	TCGA-56-8626	LUSC	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.3056
p.G603V	DO26999	LUSC	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.3056
p.G603V	DO45506	LUSC	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.3056
p.D618N	TCGA-A5-A2K5	UCEC	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	TCGA-D1-A16Y	UCEC	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	TCGA-GN-A4U4	SKCM	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	DO222363	MELA	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	DO51256	SKCM	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	DO41524	UCEC	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	DO41379	UCEC	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	SIDM00118	Colorectal Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	ACH-001081	Colon/Colorectal Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D618N	HCC2998	large intestine	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.I594V	TCGA-AD-6964	COAD	TCGA	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.0556
p.I594V	DO8360	COAD	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.0556
p.C607F	DO229038	LICA	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation altering degron motif	0.7108
p.L613P	DO229453	SKCA	ICGC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation altering degron motif	0.7582
p.V622I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.1111
p.V622I	ACH-002263	Esophageal Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.1111
p.V622I	KYSE-220	oesophagus	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.1111
p.E600D	SIDM00889	Cervical Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.E600D	SIDM00683	Prostate Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.E600D	ACH-000977	lymph node	CCLE	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.E600D	ACH-001333	Cervical Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.E600D	LNCaP-Clone-FGC	prostate	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.E600D	C-33-A	cervix	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.H610Y	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation altering degron motif	0.7229
p.H610Y	ACH-000851	Lung Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation altering degron motif	0.7229
p.E600G	ACH-001618	Leukemia	CCLE	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2222
p.D602N	HCC2998	large intestine	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2778
p.P612L	IPC-298	skin	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation altering degron motif	0.7582
p.V606I	KYSE-220	oesophagus	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation altering degron motif	0.5965
p.P615Q	OSC-19	upper aerodigestive tract	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.3056
p.E616K	NB5	autonomic ganglia	COSMIC	TQVTVLDVPDP	DEG_COP1_1	604:614	Mutation rewiring degron network	0.2778

Kaplan plot for CHL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHL1

UniProt ID: O00533

Entrez ID: 10752

Protein name: Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHL1 in