DegronMD

Uniprot ID: O00533

Source protein: Neural cell adhesion molecule L1-like protein

Source gene: CHL1

Class: DEG_COP1_1

Location: 604:614

E3 ligase: COP1

DEGRON score: 0.8156

ASA_SCORE: 53.7455

COIL: 0.5305

CONS_SCORE: 0.6396

DSS_SCORE: 0.4104

HELIX: 0.0085

FCONS_SCORE: 1.11

RIG_SCORE: 0.8021

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G603S	TCGA-17-Z049	LUAD	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.3056
p.S595Y	TCGA-55-5899	LUAD	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.0833
p.S595Y	DO26042	LUAD	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.0833
p.S595Y	SIDM01588	Endometrial Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	0.0833
p.S595Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	0.0833
p.G603V	TCGA-56-7223	LUSC	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.3056
p.G603V	TCGA-56-8626	LUSC	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.3056
p.G603V	DO26999	LUSC	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.3056
p.G603V	DO45506	LUSC	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.3056
p.D618N	TCGA-A5-A2K5	UCEC	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	TCGA-D1-A16Y	UCEC	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	TCGA-GN-A4U4	SKCM	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	DO222363	MELA	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	DO51256	SKCM	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	DO41524	UCEC	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	DO41379	UCEC	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	SIDM00118	Colorectal Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	ACH-001081	Colon/Colorectal Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D618N	HCC2998	large_intestine	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.I594V	TCGA-AD-6964	COAD	TCGA	TQVTVLDVPDP	DEG_COP1_1	0.0556
p.I594V	DO8360	COAD	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.0556
p.C607F	DO229038	LICA	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.7108
p.L613P	DO229453	SKCA	ICGC	TQVTVLDVPDP	DEG_COP1_1	0.7582
p.V622I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	0.1111
p.V622I	ACH-002263	Esophageal Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	0.1111
p.V622I	KYSE-220	oesophagus	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.1111
p.E600D	SIDM00889	Cervical Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.E600D	SIDM00683	Prostate Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.E600D	ACH-000977	lymph_node	CCLE	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.E600D	ACH-001333	Cervical Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.E600D	LNCaP-Clone-FGC	prostate	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.E600D	C-33-A	cervix	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.H610Y	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	TQVTVLDVPDP	DEG_COP1_1	0.7229
p.H610Y	ACH-000851	Lung Cancer	CCLE	TQVTVLDVPDP	DEG_COP1_1	0.7229
p.E600G	ACH-001618	Leukemia	CCLE	TQVTVLDVPDP	DEG_COP1_1	0.2222
p.D602N	HCC2998	large_intestine	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.2778
p.P612L	IPC-298	skin	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.7582
p.V606I	KYSE-220	oesophagus	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.5965
p.P615Q	OSC-19	upper_aerodigestive_tract	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.3056
p.E616K	NB5	autonomic_ganglia	COSMIC	TQVTVLDVPDP	DEG_COP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TQVTVLDVPDP

Degron related mutations and impact score

Drug responses associated with CHL1 mutations

All proteins holding degron of TQVTVLDVPDP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00533	Neural cell adhesion molecule L1-like protein	DEG_COP1_1	604:614	TQVTVLDVPDP	COP1	0.8156	More...