DegronMD - O00534(VWA5A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S402G	TCGA-BR-6566	STAD	TCGA	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1111
p.S402G	DO38217	STAD	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1111
p.T400M	TCGA-EO-A22R	UCEC	TCGA	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1667
p.T400M	DO42713	UCEC	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1667
p.T400M	SIDM00376	B-Lymphoblastic Leukemia	GDSC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1667
p.P386L	TCGA-YD-A89C	SKCM	TCGA	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.25
p.P386L	DO219501	SKCM	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.25
p.E396K	DO225190	BRCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.2778
p.E396K	DO227561	BRCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.2778
p.E391K	DO50014	BRCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation altering degron motif	0.7022
p.G384V	DO48753	LIRI	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1944
p.R392K	DO229502	SKCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation altering degron motif	0.7237
p.L400F	DO48546	SKCM	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1667
p.L400F	DO37429	SKCM	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1667
p.P393S	DO38467	STAD	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation altering degron motif	0.6752
p.L399I	DO51742	STAD	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1944
p.V398I	DO48174	UCEC	ICGC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.2222
p.Q388L	SIDM00650	Small Cell Lung Carcinoma	GDSC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.3056
p.Q388L	NCI-H128	lung	COSMIC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.3056
p.S402T	SIDM00381	Cervical Carcinoma	GDSC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1111
p.S402T	SKG-IIIa	cervix	COSMIC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.1111
p.I392M	ACH-001991	Primary	CCLE	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation altering degron motif	0.7618
p.D379N	huH-1	liver	COSMIC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.0556
p.Q404L	NCI-H128	lung	COSMIC	LFVFTD	LIG_APCC_ABBA_1	389:394	Mutation rewiring degron network	0.0556

Kaplan plot for VWA5A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWA5A

UniProt ID: O00534

Entrez ID: 4013

Protein name: von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VWA5A in