DegronMD

Uniprot ID: O00534

Source protein: von Willebrand factor A domain-containing protein 5A

Source gene: VWA5A

Class: LIG_APCC_ABBA_1

Location: 389:394

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5734

ASA_SCORE: 10.2833

COIL: 0.189

CONS_SCORE: 0.7268

DSS_SCORE: 0.2237

HELIX: 0.0065

FCONS_SCORE: 1.3277

RIG_SCORE: 0.8608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S402G	TCGA-BR-6566	STAD	TCGA	LFVFTD	LIG_APCC_ABBA_1	0.1111
p.S402G	DO38217	STAD	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.1111
p.T400M	TCGA-EO-A22R	UCEC	TCGA	LFVFTD	LIG_APCC_ABBA_1	0.1667
p.T400M	DO42713	UCEC	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.1667
p.T400M	SIDM00376	B-Lymphoblastic Leukemia	GDSC	LFVFTD	LIG_APCC_ABBA_1	0.1667
p.P386L	TCGA-YD-A89C	SKCM	TCGA	LFVFTD	LIG_APCC_ABBA_1	0.25
p.P386L	DO219501	SKCM	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.25
p.E396K	DO225190	BRCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.2778
p.E396K	DO227561	BRCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.2778
p.E391K	DO50014	BRCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.7022
p.G384V	DO48753	LIRI	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.1944
p.R392K	DO229502	SKCA	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.7237
p.L400F	DO48546	SKCM	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.1667
p.L400F	DO37429	SKCM	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.1667
p.P393S	DO38467	STAD	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.6752
p.L399I	DO51742	STAD	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.1944
p.V398I	DO48174	UCEC	ICGC	LFVFTD	LIG_APCC_ABBA_1	0.2222
p.Q388L	SIDM00650	Small Cell Lung Carcinoma	GDSC	LFVFTD	LIG_APCC_ABBA_1	0.3056
p.Q388L	NCI-H128	lung	COSMIC	LFVFTD	LIG_APCC_ABBA_1	0.3056
p.S402T	SIDM00381	Cervical Carcinoma	GDSC	LFVFTD	LIG_APCC_ABBA_1	0.1111
p.S402T	SKG-IIIa	cervix	COSMIC	LFVFTD	LIG_APCC_ABBA_1	0.1111
p.I392M	ACH-001991	Primary	CCLE	LFVFTD	LIG_APCC_ABBA_1	0.7618
p.D379N	huH-1	liver	COSMIC	LFVFTD	LIG_APCC_ABBA_1	0.0556
p.Q404L	NCI-H128	lung	COSMIC	LFVFTD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00534	von Willebrand factor A domain-containing protein 5A	LIG_APCC_ABBA_1	389:394	LFVFTD	APC,CDC20,FZR1	0.5734	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons