DegronMD - O00767(SCD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K51Q	TCGA-B5-A1MR	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation blocking ubiquitination signal	0.5556
p.K51Q	DO41758	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation blocking ubiquitination signal	0.5556
p.D52Y	TCGA-E6-A1LX	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.D52Y	DO41020	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.T37M	TCGA-FI-A2D0	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.3056
p.T37M	DO43891	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.3056
p.T37M	SIDM00980	Gastric Carcinoma	GDSC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.3056
p.T37M	ACH-000948	Gastric Cancer	CCLE	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.3056
p.T37M	ACH-000974	Endometrial/Uterine Cancer	CCLE	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.3056
p.T37M	23132-87	stomach	COSMIC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.3056
p.G31V	TCGA-SL-A6JA	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1389
p.G31V	DO219787	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1389
p.M38V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6097
p.M38V	ACH-002256	Leukemia	CCLE	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6097
p.M38V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	MPLYLE	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6097

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons