DegronMD

Uniprot ID: O00767

Source protein: Stearoyl-CoA desaturase

Source gene: SCD

Class: LIG_APCC_ABBA_1

Location: 38:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7681

ASA_SCORE: 102.0833

COIL: 0.7977

CONS_SCORE: 0.2716

DSS_SCORE: 0.5008

HELIX: 0.1497

FCONS_SCORE: 0.9358

RIG_SCORE: 0.8285

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M38V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	MPLYLE	LIG_APCC_ABBA_1	0.6097
p.M38V	ACH-002256	Leukemia	CCLE	MPLYLE	LIG_APCC_ABBA_1	0.6097
p.M38V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	MPLYLE	LIG_APCC_ABBA_1	0.6097
p.K51Q	TCGA-B5-A1MR	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	0.5556
p.K51Q	DO41758	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	0.5556
p.T37M	TCGA-FI-A2D0	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	0.3056
p.T37M	DO43891	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	0.3056
p.T37M	SIDM00980	Gastric Carcinoma	GDSC	MPLYLE	LIG_APCC_ABBA_1	0.3056
p.T37M	ACH-000948	Gastric Cancer	CCLE	MPLYLE	LIG_APCC_ABBA_1	0.3056
p.T37M	ACH-000974	Endometrial/Uterine Cancer	CCLE	MPLYLE	LIG_APCC_ABBA_1	0.3056
p.T37M	23132-87	stomach	COSMIC	MPLYLE	LIG_APCC_ABBA_1	0.3056
p.G31V	TCGA-SL-A6JA	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	0.1389
p.G31V	DO219787	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	0.1389
p.D52Y	TCGA-E6-A1LX	UCEC	TCGA	MPLYLE	LIG_APCC_ABBA_1	0.0833
p.D52Y	DO41020	UCEC	ICGC	MPLYLE	LIG_APCC_ABBA_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00767	Stearoyl-CoA desaturase	LIG_APCC_ABBA_1	38:43	MPLYLE	APC,CDC20,FZR1	0.7681	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons